The Importance of Medicines

Image There has been a spate of drug related illnesses and deaths reported from Pakistan in the press this year. In November, at least 17 people died in the eastern city of Lahore after drinking toxic cough syrup. Earlier in January, an adulterated heart medicine dispensed by the Punjab Institute of Cardiology claimed lives of at least 69 heart patients. It seems appropriate to put these happenings in some perspective.   Cough syrups have been at the center of several cases of mass poisonings around... Read More

How Are Diseases Transmitted?

Image Overview  Infectious diseases are transmitted from person to person by direct or indirect contact. Certain types of viruses, bacteria, parasites, and fungi can all cause infectious disease. Malaria, measles, and respiratory illnesses are examples of infectious diseases.  Simple preventative measures, such as frequent hand washing, can cut down on disease transmission.   Direct cont... Read More

Drug Absorption

Image Absorption is the transfer of the drug into the bloodstream. In IV this process is complete thus the whole dose reaches the systemic circulation. However in other routes of administration the rate and efficiency is dependent on many factors and usually on ly results in partial absorption. Transport in GIT Due to their chemical properties, drugs are absorbed either by passive diffusion or active transport. Passive diffusion: Passive diffusion is facilitated by the concentration gradient accross the membrane. The drug moves from ... Read More

Drug Analysis

Image What is Drugs Analysis? Within forensic science the role of the drugs section is to prove to a satisfactory level to the court, including the defence, what a substance is and ascertain whether or not it contains any drugs controlled under current legislation. To do this to the level required by the court involves performing a chemical analysis.  As well as determining exactly what drug may be in a given substance (qualitative analysis), further chemical analysis can determine the amount of the drug present and thereby provide the purity of the substance (quan... Read More

Biosensor H2O2 by Using Immobilized Horseradish Peroxidase Glutaraldehyde

Image An enzymatic biosensor has been developed for detection of hydrogen peroxide with immobilized Horseradish peroxidase (HRP). HRP was immobilized by using glutaraldehyde (GA) that cross linked with modified polyaniline (PANI) as mediator to improve electron transfer. Modified carbon paste electrodes (MCPE) PANI was more effective during electron transfer compared to carbon paste electrodes (CPE). Cyclic voltammetry method (VC) was used to determine the electrochemical properties of the modified electrode substrate to produce redox reactions. The effect of pH and temperature were analysed by c... Read More

Enzyme Enabled Antibiotic Production

Image Manufacturing is the life line and driver of economic development; by producing goods we not only achieve growth but also vastly improve our quality of life. Manufacturing in simple terms means taking certain raw materials and converting them into value added products and invariably nuisance value by-products or creating eco-impact at various levels and with more. In addition, consumption of the key material from the nature depletes the same and without a concerted eco-responsible effort the natural resource is lost for ever. Green Manufacturing Enabling... Read More

N-Acetyl Cysteine Decreases Mice Brain Acetyl Cholinesterase Activity

Image Here a kinetic in vitro study of n-acetylcysteine (NAC) on mouse brain acetylcholinesterase (AChE) activity was performed, as well, few studies with the aim to improve Ellman’s methodology based on SH contain compounds. The ideal 5,5´-dithio-bis-2-nitrobenzoic acid (DTNB) concentration was of 0.3 mM and ideal medium pH=7.4. AChE demonstrated linear activity for all acetylthiocholine iodide (ATCh) tested concentrations (0.025-0.450 mM). To avoid any DTNB-NAC interaction interference, 30 sec were applied to the assay method, so-called stabilization time. No differences i... Read More

Lipase Catalysed Trans Esterification

Image   There has been great emphasis on the use of biodiesel due to worldwide scarcity of fossil fuels, increasing crude oil prices and environmental concerns to reduce pollution. Production of biodiesel from biologically derived oils involves trans esterification of these triglycerides with short chain alcohols to yield alkyl esters of fatty acids. These can be used in engines which are having compression ignition (diesel) and are termed as “biodiesel”. Trans esterification catalysis reaction can be chemical and enzymatic by nature. The disadvantages of chem... Read More

Perioperative Management Access of Peritonitis at the Regional University Hospital of Oueme-Plateau (CHUD/OP) at Porto-Novo in Benin Republic

Image Journal of Perioperative Medicine is a peer reviewed, open access periodical that underlines the importance of pre-operative medical care, procedures and protocols in assuring stress free and healthy post-operative life of the patient. Journal of Perioperative Medicine is spotlight on Local Anesthesia, Sedation, Regional Anesthesia, Anesthetic A... Read More

Prioritisation of quality indicators for elective perioperative care: a Delphi consensus

Image Journal of Perioperative Medicine publishes high-impact original work in all branches of anaesthesia, critical care medicine, pain medicine and perioperative medicine including fundamental, translational and clinical sciences, clinical practice, technology, education and training. The journal has a well-respected editorial board and provides a sharp focus on the topics and issues facing the profession of Internal Medicine with a combination of society news, clini... Read More

Non Pharmacological Use of Daucus Carota Juice (Carrot Juice) as Dietary Intervention in Reducing Hypertension

Image The word diuresis is derived from the Greek word ourein which means ‘’to urinate’’. The diuretic agents are not only involved in the excretion of water but also capable to remove or excrete other urinary constituents which may be beneficial in the treatment of different conditions like hypertension, edema. Diuretic agents reduce morbidity and mortality related to stroke and congestive heart failure in hypertensive patients. Hypertension can be defined as sustained increase in systolic blood pressure greater than 140 mmHg and diastolic pressure greater than ... Read More

Impacted Cera Septal Occluder Device in Right Ventricular Outflow Tract (RVOT): A Potential Challenge for the Anesthesiologist

Image Journal of Perioperative Medicine publishes original work of high scientific quality. Preference is given to experimental work or clinical observation in man, and to laboratory work of clinical relevance. Journal of Perioperative Medicine also publishes commissioned narrative reviews by an authority in a field of interest to those working in anaesthesiology, pain, emergency medicine or intensive care. Editorials, commissioned commentaries and book reviews also included.... Read More

Purification Propensity for Proteins from Bacillus halodurans

Image The demand for proteins with special purposes increases significantly. These proteins are generally obtained through recombinant proteins; however their purification is costly and not easy. It is necessarily important to develop a method to estimate the chance of purification beforehand in order to have a prospective on proteins in question. Purification of a protein should be related to instinct properties of a protein including its 3D structure, and so far around 540 amino acid properties are found. Thus it is possible to test each amino acid property against the successful rate... Read More

Modeling Analyses on the Success Rate of Purification of Saccharomyces cerevisiae Proteins

Image Saccharomyces cerevisiae is the most widely used yeast in research and industries, however the downstream processes for its protein production are costly. This study attempted to find out a simple way to predict the success rate of protein purification with amino acid features. Logistic regression and neural network model were used to test each of 535 amino acid features one by one against the purification state of 1294 expressed proteins from S. cerevisiae, of which 870 were purified. The results show that the predictive performance of neural network is more powerful than that of... Read More

Impacted Cera Septal Occluder Device in Right Ventricular Outflow Tract

Image Journal of Perioperative Medicine is an open access journal that publishes highly topical clinical research relating to the perioperative care of surgical patients.  Journal of Perioperative Medicine   essence is the distillation, examination and application of clinical evidence to improve surgical outcome. Modern perioperative medicine is a true multidisciplinary speciality and the journal welcomes research in all areas relevant to perioperative medicine fr... Read More

Torsion of Para-Ovarian Cyst

Image Single-Blind Peer Review Journal devoted to the clinical practice of anaesthesia. Journal of Perioperative Medicine a wide range of articles in the discipline of anesthesiology including basic science, translational medicine, education, and clinical research to create a platform for the authors to make their contribution towards the field without restrictions/ barriers of subscription and language. ... Read More

Cephalosporin C Production from Acremonium chrysogenum

Image Cephalosporin C demand is increasing worldwide because of its enhanced antibacterial spectrum that it can be used to treat diseases and infections caused by Gram positive/or Gram negative bacterial strains. Cephalosporin C is easily produced from the fungus Acremonium chrysogenum by the process of fermentation in a bioreactor under optimum reaction conditions to obtain maximum yield of the antibiotic. Additional chemical and structural modifications in the existing cephalosporin C could further enhance its antimicrobial spectrum. Acremonium chrysogen... Read More

Anaesthesia and Perioperative Care

Image Journal of Perioperative Medicine (JPME) is an international, peer reviewed, open access journal committed to publish innovative research in the field of anaesthesia and pain medicine. Anaesthesia means temporary ‘loss of sensation or awareness' usually given as gas to breathe in, injections, ointments, drops or sprays to stop the painless performance of medical procedures. It is usually given as gas to breathe in, injections, ointments, drops or sprays. ... Read More

Enzyme Expression

Image The metabolic enzyme expression remodelling is now widely known as hallmark of cancer, but it is not clear whether individual metabolic strategies are frequently exploited by many tumours. The highest scoring pathway is mitochondrial one-carbon metabolism and protein are markedly elevated in many cancers and correlated with poor survival in breast cancer. In this it shows the importance of mitochondrial compartmentalization of one carbon metabolism in cancer and raises important therapeutic hypotheses. Enzymes are an important staple in the biopharmaceutical, agricultural and chem... Read More

Bioprocess

Image A bioprocess is a specific process that uses complete living cells or their components (e.g., bacteria, enzymes, chloroplasts) to obtain desired products. Transport of energy and mass is fundamental to many biological and environmental processes. Areas, from food processing (including brewing beer) to thermal design of buildings to biomedical devices to pollution control and global warming, require knowledge of how energy and mass can be transported through materials (momentum, heat transfer, etc.). Cell bioprocessing: Cell therapy bioprocessi... Read More

Potential Challenge for the Anaesthesiologist

Image Journal of Perioperative Medicine is multidisciplinary medical field related to perioperative care of surgical patients. Journal of Perioperative Medicine is medical patient care from the time of contemplation of surgery to recuperate from surgical period to improve the surgical outcome. Surgeon, anesthetist, intensivist and physician work closely in such field. However anesthetist play major role in perioperative medicine from pre anesthesia check prior to surgery. ... Read More

Biochemical Changes and Cardiovascular Function

Image Clinical & Medical Biochemistry  covers the research areas in the field of Clinical Biochemistry, Pathological, Microbiological, Molecular, Cellular, Genetic and Bioinformatics concepts and other advanced techniques. The journal primary mission to serve the public interest in health care by providing leadership in clinical laboratory science to national professional societies, the diagnostics industry, government and non-government organization. Journal of Clinical... Read More

Evaluation of the Ophthalmology

Image Publishing highly topical clinical research relating to the perioperiative care of surgical patients, Journal of Perioperative Medicine  aims to disseminate the distillation, examination and application of clinical evidence to improve surgical outcome. Understanding that modern perioperative medicine is a multidisciplinary speciality, we welcome research in all areas relevant to perioperative medicine from any healthcare professional. ... Read More

Care of the Mother and Neonate

Image   Journal of Pregnancy and Neonatal Medicine(JPNM) is an open access, peer reviewed, scholarly journal that focusses on the publication of research developments in the various aspects of fertility, pregnancy, child birth and neonatal care. Pregnancy and neonatal medicine research are of high significance and it is indispensable for assuring the good health of new mothers and babies. Journal of Pregnancy and Neonatal Medicine(JPNM) integrates ... Read More

Inviting you to Join as an Editorial Board: Open Access Journal

Image Inviting you to Join as an Editorial Board: Open Access Journal    “Journal of Thyroid Disorders & Therapy” offers the most comprehensive and reliable information pertaining to the latest developments in the field. The Journal also believes in advancing new hypotheses and opinions by means of its high-quality Reviews, Perspectives, and Commentaries. Thus, the content published in the journal is original and comprehensive. Manuscripts are subjected to rigorous peer review, where acclaimed scientists that are part of the... Read More

Journal of Forensic Biomechanics would like to celebrate its thanksgiving by Providing High Discounts on APC

Image Journal of Forensic Biomechanics is a peer-reviewed scholarly journal and aims to publish the most complete and reliable source of information on the discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc. covering forensic biomechanics, ... Read More