Designed Alteration of Binding Affinity in Structure-Switching Aptamers through the Use of Dangling Nucleotides

Image

Clinical & Medical Biochemistry journal provides an international forum for publishing exceptional, rigorous, high-impact research across all of biological chemistry. This broad scope includes studies on the chemical, physical, mechanistic, and/or structural basis of biological or cell function, and encompasses the fields of chemical biology, synthetic biology, disease biology, cell biology, nucleic acid biology, neuroscience, structural biology, and biophysics. In addition to traditional Research Articles, Clinical & Medical Biochemistry journal also publishes Communications, Viewpoints, and Perspectives, as well as From the Bench articles that report new methods of particular interest to the biological chemistry community.

The Clinical & Medical Biochemistry journal publishes the results of original research in the fields of Biochemistry, Molecular Biology, Cell, and Biotechnology written in English in the form of Regular Papers or Rapid Communications. A Rapid Communication is not a preliminary note, but it is, though brief, a complete and final publication. The materials described in Rapid Communications should not be included in a later paper. The Journal also publishes short reviews (JB Review) and papers solicited by the Editorial Board.

Due to the COVID-19 situation, we fully understand most labs are fully or partially shut down so please let us know if you need additional support and contact your Editor to ask for an extension of your revision if you need one.

Manuscripts are categorized as Analytical or Clinical Investigations and may be offered as Full Papers, Short Communications, or Letters. Opinion pieces and Special Reports are welcome, but contributors are encouraged to contact the Editor-in-Chief to avoid conflict with other forthcoming publications. The journal is successfully running volume 6 with a large number of viewers from around the world.  

The writing style should be concise and accessible, avoiding jargon so that the paper is understandable for readers outside a specialty or those whose first language is not English. Editors will make suggestions for how to achieve this, as well as suggestions for cuts or additions that could be made to the article to strengthen the argument. Our aim is to make the editorial process rigorous and consistent, but not intrusive or overbearing. Authors are encouraged to use their own voice and to decide how best to present their ideas, results, and conclusions. Although we encourage submissions from around the globe, we require that manuscripts be submitted in English. Authors who do not use English as a first language may contact us for additional information. As a step towards overcoming language barriers on acceptance of the paper, we encourage authors fluent in other languages to provide copies of their full articles or abstracts in other languages. We will publish these translations as supporting information and list them, together with other supporting information files, at the end of the article text.

Regards,

Martini Jones,

Managing Editor,

London, UK

Clinical and Medical Biochemistry

Whatsapp: +3225889658